You are not your brain – Alva Noe’s new book

Just got a new book by Alva Noe: Out of Our Heads: Why You Are Not Your Brain, and Other Lessons from the Biology of Consciousness.

Description from the book jacket:

lva Noë is one of a new breed—part philosopher, part cognitive scientist, part neuroscientist—who are radically altering the study of consciousness by asking difficult questions and pointing out obvious flaws in the current science. InOut of Our Heads, he restates and reexamines the problem of consciousness, and then proposes a startling solution: Do away with the two hundred-year-old paradigm that places consciousness within the confines of the brain.
 
Our culture is obsessed with the brain—how it perceives; how it remembers; how it determines our intelligence, our morality, our likes and our dislikes. It’s widely believed that consciousness itself, that Holy Grail of science and philosophy, will soon be given a neural explanation. And yet, after decades of research, only one proposition about how the brain makes us conscious—how it gives rise to sensation, feeling, and subjectivity—has emerged unchallenged: We don’t have a clue.
 
In this inventive work, Noë suggests that rather than being something that happens inside us, consciousness is something we do. Debunking an outmoded philosophy that holds the scientific study of consciousness captive, Out of Our Heads is a fresh attempt at understanding our minds and how we interact with the world around u

Alva Noë is one of a new breed—part philosopher, part cognitive scientist, part neuroscientist—who are radically altering the study of consciousness by asking difficult questions and pointing out obvious flaws in the current science. InOut of Our Heads, he restates and reexamines the problem of consciousness, and then proposes a startling solution: Do away with the two hundred-year-old paradigm that places consciousness within the confines of the brain. Our culture is obsessed with the brain—how it perceives; how it remembers; how it determines our intelligence, our morality, our likes and our dislikes. It’s widely believed that consciousness itself, that Holy Grail of science and philosophy, will soon be given a neural explanation. And yet, after decades of research, only one proposition about how the brain makes us conscious—how it gives rise to sensation, feeling, and subjectivity—has emerged unchallenged: We don’t have a clue. In this inventive work, Noë suggests that rather than being something that happens inside us, consciousness is something we do. Debunking an outmoded philosophy that holds the scientific study of consciousness captive, Out of Our Heads is a fresh attempt at understanding our minds and how we interact with the world around us.

This book is really exciting to me as I am beginning to see the light in the end of the neuroscience/cognitive science tunnel in the image of neurophilosophy, neurophenomenology and, specifically, embodied approach to the human cognition/experience. Having a humanities background, I’ve always struggled with the current neuroscience framework, both professionally and on the personal level. Psychology in general and neuroscience/cognitive science in particular, have been dramatically moving away, severing all ties with philosophy and other humanities, striving for objective empirical science that is somehow free from all subjectivity. While many see it as a great achievement, some, myself included, feel that there must be a place for phenomenal and experiential in psychology if what we truly want is to better understand human consciousness. 

I can’t wait to read it, I enjoyed Varela, Thompson and Roch’s The Embodied Mind: Cognitive science and human experience, as well as Thompson’s Mind and Life. And I’m hoping that publication of this book signifies that this emerging domain which brings together the best in neuroscience, phenomenology and philosophy, will be taken seriously to challenge existing ontologies and will help us better understand the human condition in its richness and awesomness. 

If my baby’s nice and she starts taking long naps I might even read it before the end of the month… 

Here you can read an interview with Alva Noe about his new book.

And here you can watch and hear Alva Noe talk about consciousness and life.

Elsevier scandal: drugs and arms

A couple of weeks ago blog posts here and here somewhat confirmed everyone’s paranoid delusions that there exists a ‘conspiracy’ between pharmaceutical companies and journals publishing favorable results. Merck, a “global research-driven pharmaceutical company dedicated to putting patients first” which is “commited to making a difference”, made a difference big time this time: everyone please welcome Australasian Journal of Bone and Joint Medicine!

Australasian Journal of Bone and Joint Medicine

From The Scientist (via Wikipedia):

Merck paid an undisclosed sum to Elsevier to produce several volumes of [Australasian Journal of Bone and Joint Medicine], a publication that had the look of a peer-reviewed medical journal, but contained only reprinted or summarized articles—most of which presented data favorable to Merck products—that appeared to act solely as marketing tools with no disclosure of company sponsorship

According to this article on news inferno, one of the catalysts for investigation into this journal was a lawsuit by a patient who suffered a heart attack while on Vioxx – one of Merck’s creations which ended up being so dangerous it was recalled from circulation. We’re not talking about vitamins here, but rather about arthritis medication and vaccines. Worse still, Merck, one of the most powerful companies in the Big Pharma, is known to hold a sort of a blacklist for doctors who speak out against its drugs.

This journal does not have its own website, and was published by Elsevier, probably the biggest peer-reviewed publishing company which publishes about 2000 journals, many of which are highly reputable in their field. Here’s what an Elsevier representative had to say about the fake journal:

I wish there was greater disclosure that it was a sponsored journal

Nice, right? I mean, now I definitely will look into any journal that has Australasian in its title… sounds suspicious to me! But it wouldn’t sound too suspicious to busy doctors prescribing medications simply because it is published by Elsevier, a leader in peer-revewed publishing, established in 1880!

Peer-review may be a flawed process, it is subject to pressing politics, changing ontologies and, sometimes even luck, but it is the best system we have so far. And even it it were not, it is the rules of the game of scientific publications. We agree on it, and we expect it to be rigorous and, as much as possible, objective. At the very least, professional and skeptical.

So this scandal provoked much outrage and discussion over the last 2 weeks (and rightly so), with people wondering how many more instances of similar examples of academic dishonesty and fraud we don’t know about. And here’s where it gets really interesting. It gets better and better:

Following Merck story, librarians have found at least six more phony pseudo peer-reviewed journals published by Elsevier (more here), which were confirmed, as well as about 50 more potential journals (more here)… Wikipedia has an interesting overview of other controversies surrounding Elsevier, such as resignation of entire editorial boards of prestigious journals because of high prices imposed by the company, editors misusing their position to promore their own research, and, the best part is that the CEO of Elsevier, Reed Elsevier, had been involved in the arms industry.

The Lancet, among others, one of Elsevier’s most prestigious journals, urged Elsevier to severe its ties with weapons industry, seeing it as incompatible with health and legal research. The good news is that there was enough pressure, and Elsevier is no longer associated with defence industry. From Times Online:

Sir Crispin Davis, chief executive, said: “Our defence shows are quality businesses, which have performed well in recent years. Nonetheless, it has become increasingly clear that growing numbers of important customers and authors have very real concerns about our involvement in the defence exhibitions business.

“We have listened closely to these concerns and this has led us to conclude that the defence shows are no longer compatible with Reed Elsevier’s position as a leading publisher of scientific, medical, legal and business content”

yeah…

It’s kinda morbidly funny… maybe Elsevier arms industry is part of a novel research strategy… first you mutilate bodies, then you fix them, and then publish the results in Australasian Journal of Bone and Joint Medicine, right?

The awesomest dream sequence I’ve ever seen

At the end of Twin Peaks season 1 episode 2 special agent Cooper has a dream:

I am not a big fan of the first part, the images seem too disconnected and more like a stereotypical fuzzy dream sequences that we have seen a million times in cinema, but the part in the red room is fantastic. I particularly like the use of backwards video and audio recording, as well as Cooper’s apparent paralysis and inefficiency.. it’s one of these dreams where something important is revealed to you, and you wake up in a state of elation only to realize moments later that you cannot remember what it was about…

Another thought: there are dreams that help us solve specific problems, like the night before an exam, or when working on a particular dilemma. These thoughts that occupy all our time follow us into the dreamland as well. Then the first part of this sequence, mainly consisting of images and plain short monologues could perhaps be seen as sleep onset and then stage 2 dreaming – not very elaborate, with some minimal imagery, with more wake-like thoughts… and later, the red room is a full-blown REM dream with elements of muscle atonia, possibly sleep paralysis, following the rules of its own.

Play puzzles and contribute to science – Foldit

I don’t really like playing computer games, but I must say I have a soft spot for puzzles. When I discovered sudoku, about two years ago, I played it nonstop for almost three weeks, after which I got tired of wasting so much time without getting anything done…

And then, after reading BoingBoing a couple of days ago, I discovered Foldit!

This free downloadable game is a product of collaboration between departments of Computer Science and Engineering and Biochemistry of University of Washington.

Scientists today have a pretty good idea about the amino acid sequence in proteins, but understanding how amino acid sequences fold into a three-dimensional structure require a lot of computational power since there can be close to an infinite number of solutions. And shape of proteins is important in determining the kinds of interactions that a protein can have. Understanding and, eventually synthesizing proteins requires understanding of both amino acid sequences and of protein shape in space. The idea of the game is to use human brain, and especially people’s love for 3-dimentional puzzles to determine an optimal way in which a given protein would fold. Since there is no true solution, the score is attributed in relation to how much energy is needed to sustain the protein in the shape that you created. The challenge is not to ‘solve’ the puzzle, but to beat other players’ scores. The ‘best’ solutions are then analyzed by scientists and, hopefully, human players can figure things out faster than computers.

Picture 10Players create groups, share solutions and compete agains each other. The principles behind each protein puzzle are simple enough yet challenging: proteins have to be compact, hydrophobic moleculs should stay inside the structure, and all elements have to be apart enough not to clash and to permit biochemical processes to take place.

In the current stage, players solve puzzles concerning proteins shapes of which we already know. The scientists are collecting data hoping that human participants are more effective than computer in determining the optimal shape of protein folding. If they are right, then later new puzzles will tackle proteins that are currently not well understood, and the game will also be potentially useful in designing new proteins, which has implications for virtually all areas where biochemistry is involved: from finding a cure for cancer to lessening the effect of global warming.

Here you can download Foldit (Windows, Mac and Linux).

Sheep are dreaming in utero

A cool article in Chaos: an Interdisciplinary Journal of Nonlinear Science  of the American Institute of Physics: “Nonlinear analysis and modelling of cortical activation and deactivation patterns in the immature fetal electrocorticogram”.

chaos pictureFetal sheep were implanted in utero electrodes and their brain activity was recorded at .7 and .9 gestation time (106 and 130 days). With complicated nonlinear mathematical analyses, cyclical activity was visible as early as at .7 gestation time. Although this activity was different from later (at .9 gestation time) clear REM-NREM division, patterns of cortical activation and deactivation, somewhat similar to REM and NREM sleep were already present. So early fetal sleep has its own alternating cyclical patterns, which, at a certain developmental moment change into familiar sleep architecture which then is relatively stable during the adulthood.

Article: synthetic cannabis reduces PTSD nightmares

An article in the latest issue of CNS Neuroscience and Therapeutics:

CNS article

PTSD patients with recurrent nightmares were administered nabilone, a synthetic cannabinoid, in an attempt to reduce or better manage their traumatic nightmares. 72% of patients in this study reported either cessation of nightmares or reduction of nightmare intensity during treatment.  

It is now known that cannabis and synthetic THC significantly reduce REM, facilitate falling asleep and increase deep sleep (stage 4) duration (see Schierenbeck et al (2008) in Sleep Medicine Reviews), so in case of PTSD REM-related nightmares it would seem logical to use cannabinoids. However, systematic REM deprivation usually provokes dramatic rebounds. In fact, marijuana withdrawal often produces increased dreaming and, especially, more intense and strange dreams. 

In the present article, only 4 out of 47 patients reported successful discontinuation of medication with either complete cessation or reduction of nightmares. However, other patients reported return of nightmares when taken off the medication, and needed to continue treatment.

While it seems plausible that cannabinoids could be useful in treatment of acute cases of PTSD-related nightmares, permitting the patients to get better sleep and perhaps interfere with some pathological memory consolidation processes which replay traumatic experiences despite the passage of time; its long-term use as a continuous therapy is questionable. Changing sleep architecture will perhaps interfere with normal memory consolidation and healing processes which are essential in treatment of PTSD, and rebound effect may just not worth it. Systematic use of cannabinoids does not just eliminate nightmares, it reduces all dreaming, which must have an effect on all spheres of mental functioning.

A facebook group for oneiricum blog

I just created an open facebook group for this blog: feel free to join and exchange thoughts and ideas!

Beatles for meditation

From today’s article in New York Times: Paul McCartney and Ringo Starr reunite for a concert in support of David Lynch’s foundation that promotes transcendental meditation for children. The slogan of the Lynch foundation says: “for consciousness-based education and word peace”, and his personal message ends with:

By offering Consciousness-Based education to the coming generation, we can promote a strong foundation for a healthy, harmonious, and peaceful world. For this, the Foundation also supports the establishment of Universities of World Peace that will train the coming generation in a new profession: that of professional peacemaker.

Meditation changes your brain

row of buddhas

Recently there have been an explosion of psychological and neuropsychological studies of meditators. Perhaps it can be seen as the sign that mainstream science of the mind is finally opening up to so-called “alternative” or traditional approaches, and it may be an important step towards a more integrative and more inclusive and interdisciplinary understanding of how human mind works. I seems to me that the reluctance with which contemporary neuroscience deals with traditional healing techniques and theories of the mind attests to some sort of youth or immaturity of the discipline that is trying hard to develop its own framework and coherent picture of how things work, and in order to do so successfully it just has to reject all the old types of knowledge, and even define itself against this vast repository of stuff. Sort of like an adolescent rebelling against parental values. What I always had difficulty understanding is why do we think today that we understand our world and our bodies so much better than our ancestors? Is our worldview really any more meaningful, coherent and sensible than it was hundreds of years ago?

In the past decade, however, meditation practices are reaching greater number of people of a great variety of socio-cultural backgrounds and religious affiliations, and are no longer seen as cultural artifacts of some mysterious past. Meditation techniques are being successfully used in psychotherapy, and in most major cities in the West there are a number of centres which offer instruction of different types of meditation.

And so neuroscience is now opening its doors to these techniques in an attempt to better understand what is actually happening in human brain during meditation. Breakthroughs in brain imaging techniques now allow to glimpse into the subtle but important structural changes associated with these practices. There is a number of articles dealing with this, but here are a couple of most recent ones.

Luders et al  (2009) in the prestigious journal Neiroimage in their MRI study of long-term meditators report larger grey matter volumes in the orbito-frontal cortex and in right hippocampus – brain regions thought to be implicated in a variety of important functions, including emotion regulation, memory consolidation and retrieval (hippocampus) and control of behaviour (orbito-frontal cortex). In other words, meditation promotes and protects mindfulness-related brain areas.

Furthermore, meditation practices have a beneficial effect on deeper brain structures, which control functions that are normally not accessible for conscious control. Vestergaard-Poulsen et al (2009) in Neuroreport have found that long-term meditators also have greater grey matter density in lower brainstem, deeper, more evolutionary primitive part of the brain which is primarily concerned with autonomic functions, such as cardiorespiratory control. 

These findings, together with numerous other meditation studies, once again challenge the predominant machinic, or computational view of human cognition as a function of input-output system, like a computer. Instead, they point towards the idea that mind and body can influence each other in a bi-directional way, that mind affects brain just as much as brain affects mind, and so in a circular autopoietic way.

Article: Embodied perspective on nightmares and sleep paralysis in Puerto Ricans

article1

I received a recent PubMed update for “what’s new for sleep paralysis” a week ago, and found this interesting article. It is very unusual to get interdisciplinary and cross-cultural stuff from PubMed updates, so I got immediately intrigued. First of all, I am a big fan of sleep paralysis and related paraphernalia – alien abductions, sense of presence, ominous entities – this kind of intense hallucinatory stuff really mixes well physiological and cultural, to show that the two are very intimately entangled in creating embodied and lived phenomenology of an experience.

In this paper the author uses the term “nightmare” in its old etymological sense: to refer both to nightmares (REM sleep dreams) and sleep paralysis (vivid hallucinations at sleep onset or upon awakening accompanied by body paralysis). He takes on an interdisciplinary approach, drawing on both cognitive science and cultural anthropology to examine the phenomenology of these various nightmare experience and their relation to trauma in Puerto Ricans. What I find particularly interesting is that “waking” nightmares (sleep paralysis) are considered as traumatic events, and “sleep” nightmares (REM-related events) are then perturbed in re-living some real life trauma. In other words, sleep paralysis can be seen as REM mechanisms intruding into wake to produce a traumatic disturbance, and then nightmares are disturbed REM phenomena that draw on waking experiences.

The article examines these traumatic narratives, including sleep paralysis related sensed presence manifestations such as Suffocating Sombras and Sexual Incubus, as well as Frightened Flight, Loss and Grief, and Posttraumatic nightmares

Traumatic nightmares (both REM dreams and sleep paralysis) are situated within a continuum of alrered states of consciousness, somewhere along the line with visions, shamanic trance experiences and such. This continuum (adapted from studies of psychological anthropologist Bourguignon) includes any dissociative experiences that “in which contact with self and others is modified in some particular way”. The continuum looks like this:

picture-6

The phenomenology of embodied perception (from Merleau-Ponty) is then addressed using socio-cultural framework drawing a great deal on religious and supernatural beliefs and structures that bring forth a meaning of the traumatic experience, whether it deals with sleep paralysis related supernatural assault trauma or with traumatic events relived in nocturnal nightmares. Nightmare experiences are seen as embodied, both on the perceptual level and on the level of bodily memory, whereas strong emotional reactions create specific kinesthetic and proprioceptive traces.

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